独自生活在运河边农村的老太太周瑾(葛兆美 饰)突然被确诊脑瘤,漂在外地的子女不得不回乡照顾。大女儿苏念真(刘丹 饰)在上海经营留学咨询机构,正在经历第二次离婚,她坚持要给母亲最好的治疗;小儿子苏念清(吴洲凯 饰)是个四处漂泊的导游,他支持母亲放下,接受无常。在死亡面前,周瑾寻找着精神的归宿 ,苏念真和苏念清在不断发现母亲秘密的同时,正与故乡失去最后的连接。Jin, an aged mom living alone in a village, has been diagnosed with a brain tumor. After knowing this bad news, her daughter Jenny, who runs an English training center in Shanghai, struggling to make both her business and second marriage work, insists to find the best treatment for Jin. However, Jenny's younger brother Qing, who works as a tourist guide, believes what is going to happen will eventually happen and encourages the family to embrace this harsh reality. Accompanied by families, Jin spends the last few months of her life finding her final \"destination\". Meanwhile, Jenny and Qing find that they are losing the connection with the hometown. The story has been narrated poetically with authentic portraying each character. Time flies, things change, but the village is always staying alongside the river and witnessing all the farewells.