影片《征服四海》讲述哥伦布(乔治斯·科拉菲斯 饰)曾经的奇幻航海历程的故事。哥伦布在航海的道路上遇到了很多问题,经历过生死边缘,在自己的努力中,他最终完成了心目中的航海历程。Genoan navigator Christopher Columbus has a dream to find an alternative route to sail to the Indies, by traveling west instead of east, across the unchartered Ocean sea. After failing to find backing from the Portugese, he goes to the Spanish court to ask Queen Isabella and King Ferdinand for help. After surviving a grilling from the Head of the Spanish Inquisition Tomas de Torquemada, he eventually gets the blessing from Queen Isabella and sets sail in three ships to travel into the unknown. Along the way he must deal with sabotage from Portugese spies and mutiny from a rebellious crew.